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D
I G I G E N E
There
are one billion words in the book, which makes it longer than 5,000
volumes the size of this one, or as long as 800 Bibles. This is
gigantic document, an immense book, a recipe of extravagant length,
and it all fits inside the microscopic nucleus of assign cell that
fits easily upon the head of a pin.
The
idea of the genome as a book is not, strictly speaking, even a metaphor.
It is literally true. A book is a pice of digital information, eritten
in linear, one dimensional and one-directional form and defined
by a code that transliterates a small alphabet of signs into a large
lexicon of meanins through the order of their groupings.So is a
genome. The only complication s that all English books read from
left to right, and some from right to left, though never both at
the same time.
Whereas
English books are written in words of variable length using twenty-six
letters, genomes are written entirely in three- letter words, using
only four letters: A,C,G and T (which stand for adenine, cytosine,
guanine and thymine). And instead of being written on flat pages,
the are written on long chains of sugar and phosphate called DNA
molecules to which the bases are act as side rungs. Each chromosome
is one pair of (very) long DNA molecules.
The
genome is very clever book, because in the right conditions can
both photocopy itself and read itself. The photocopying is known
as REPLICATION, and the reading as TRANSLATION. replicaion works
because of an ingenious property of he four bases: A likes to pair
with T, and G with C. S o a single strand of DNA can copy itself
by assembling a complementary strand with Ts opposite all the As,
As opposite all the Ts, Cs opposite all the Gs and Gs opposite all
the Cs. In fact, usual state of DNA is the famous DOUBLE HELIX of
the original strand and its complementary pair intertwined.
To
make a copy of the complementary strand therefore brings back the
original text. So the sequence ACGT become TGCA in the copy, which
transcribe back to ACGT in the copy of the copy. This enables DNA
to replicate indefinitely, yet still contain the same information.
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